Review: antileukotrienes are less effective than inhaled corticosteroids in chronic asthma
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چکیده
منابع مشابه
Review: antileukotrienes are less effective than inhaled corticosteroids in chronic asthma.
and commentary also appear in ACP Journal Club. Therapeutics EBM Volume 8 March/April 2003 49 www.evidence-basedmedicine.com group.bmj.com on June 22, 2017 Published by http://ebm.bmj.com/ Downloaded from
متن کاملReview: adding antileukotrienes to inhaled corticosteroids reduces exacerbations in symptomatic chronic asthma.
M a i n r e s u l t s 13 trials (12 in adults and 1 in children) were included. Combining data from 2 of the 6 trials in symptomatic patients and after 4 to 16 weeks of treatment showed that the addition of higher-than-licensed AL doses to ICS reduced the risk for exacerbations requiring systemic corticosteroids (Table). The addition of higher-than-licensed doses also led to an improvement in F...
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Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal accumulation of basophils, eosinophils, lymphocytes, mast cells, macrophages, dendritic cells, and myofibroblasts. Airway inflammation is not limited to severe asthma, but is also found in mild and moderate asthma. This inflammation results in a peculiar type of lymphocytic infiltration whereby Th2 lymphocy...
متن کاملReview: antileukotriene agents at licensed doses plus inhaled corticosteroids do not reduce asthma exacerbations more than inhaled corticosteroids alone.
M e t h o d s Data sources: Cochrane Airways Group Asthma trials register, Cochrane Central Register of Controlled Trials, references of relevant articles, pharmaceutical companies manufacturing ALs and ICSs, and abstracts of the American Thoracic Society and European Respiratory Society Meetings (1998 to 2003). Study selection and assessment: Randomized controlled trials (RCTs) comparing ALs p...
متن کاملInhaled corticosteroids in asthma management.
Asthma is a disorder of the lower airways, characterized by bronchial hyperresponsiveness and airflow limitation, the pathogenesis of which is yet to be fully understood. Regardless of its triggers, asthma's hallmark is a state of inflammation that, when uncontrolled, results in persistence of symptoms. Inhaled corticosteroids are established as the mainstay of asthma therapy. This paper examin...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2003
ISSN: 1356-5524
DOI: 10.1136/ebm.8.2.49